However, the most common symptom is a severe headache, sometimes occurring within 10 hours (sometimes ~30 minutes) that does not respond to aspirin. The occurrence of systemic illness is variable. The fully developed lesion may reach 3 cm or more in diameter which may take several months to heal and often leave permanent scars. In some cases, tissue loss is so severe that surgical removal of damaged tissue and repair are needed. A scab can develop over necrotic tissue that eventually sloughs off. Blisters form within 12-48 hours, which eventually crust over the cratered wound. This bite area will be surrounded by an expanding red welt that can reach 5-15 cm in diameter. Pain might not be associated with the bite, but a small hard area may appear within 30 minutes of the bite. The impact of a hobo spider bite is much like the brown recluse spider. Because hobo spider bites are often mistaken for the brown recluse spider bite, it is always a good idea to bring in the spider if possible when seeking medical attention, which should be immediately after any spider bite. The hobo spider bite is not considered to be fatal, however the spider’s venom is strong enough to cause local pain and also to cause tissue death at and near the bite.

The blister will break in around 24 hours, and the wound left behind generally will heal very slowly. Within 15 to 35 hours the sore will blister. The initial bite by the hobo spider usually is not painful, but in about thirty minutes a hard area will appear. A hobo spider will usually bite a human due to getting trapped in clothing, in bed sheets, and being trapped next to the skin. However, when a hobo spider is tending to their eggsacs they tend to become even more aggressive and at that point they may attack a human. The hobo spider is not an aggressive spider by nature and will generally avoid humans. Hobo spiders have been known to sometimes build their webs in or around human habitats. The hobo spider hides in the back of the funnel waiting for something to get caught in the web.

The hobo spider will trap insects that cannot maneuver the funnel surface. The hobo spider is a funnel-weaving spider, which means the web that it produces is not sticky, but rather it is meant to be a trip web. The males search for female hobo spiders during mid-summer until early fall, so that is the time when they are most likely to be seen. The hobo spider is usually seen running across floors. The females also have these palps, but they look different, as they are not swollen like the males. The palps, which is the male genitalia is often mistaken for fangs or venom sacs. Appearance wise, males are notably different from females in that they have two large palps.

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